What it is
DSIP is a nine-amino-acid peptide first found in rabbits in the 1970s, when researchers were looking for natural sleep signals.
Despite its name, scientists still have not found a clear gene or receptor for it in humans, and its role in sleep is uncertain.
US regulatory status
Not FDA-approved. The FDA removed it from its Category 2 compounding list in April 2026, but in July 2026 an FDA advisory committee voted 6-7 against recommending it for compounding.
What the research shows
Older human studies from the 1970s and 1980s gave mixed results, with some showing small sleep changes and others showing none. Modern, well-controlled trials are lacking.
How it is given
Injection or nasal spray (unapproved)
Commonly reported side effects
- Headache
- Daytime sleepiness
- Nausea
- Limited human safety data
Questions to ask your provider
- What could be behind my sleep problems?
- Which proven sleep treatments or habits might help me?
- Should I have a sleep study?
Informational only. We are not doctors. PepSteady does not give medical advice, diagnose, or recommend doses, and we do not sell peptides. Always follow your licensed healthcare provider and pharmacist.