What it is
Gonadorelin is a man-made version of gonadotropin-releasing hormone (GnRH), the brain signal that tells the pituitary to release LH and FSH.
When given in pulses it can stimulate the reproductive system. It has been used to test pituitary function and to support ovulation.
US regulatory status
Human gonadorelin products were FDA-approved in the past (Factrel as a diagnostic, Lutrepulse for ovulation induction), but those products are listed as discontinued; FDA-approved gonadorelin products today are veterinary. Some licensed pharmacies prepare compounded gonadorelin by prescription, and these are not FDA-reviewed for safety or effectiveness.
What the research shows
Gonadorelin's role in testing pituitary function and stimulating ovulation is well documented in older studies. Evidence for popular off-label uses, such as keeping testicular function during testosterone therapy, is limited and mostly observational.
How it is given
Subcutaneous injection (compounded vial)
Commonly reported side effects
- Injection site pain or swelling
- Headache
- Nausea
- Flushing
- Rare allergic reactions
Questions to ask your provider
- Is there an FDA-approved option for my situation, such as hCG?
- How will we monitor my hormone levels?
- What are the pros and cons of a compounded product for me?