What it is
Melanotan II is a lab-made version of alpha-MSH, a hormone that triggers skin tanning. It acts on several melanocortin receptors in the skin and brain.
Because it affects more than skin color, it can also change appetite and sexual function. Bremelanotide (Vyleesi) was developed from it.
US regulatory status
Not FDA-approved. The FDA has issued warning letters against companies selling melanotan tanning products, and it was removed from the Category 2 compounding list in April 2026 with an advisory committee review planned by early 2027; it is not an accepted bulk substance for compounding.
What the research shows
Small early human studies showed it can darken skin. Doctors have published case reports of new or changing moles, melanoma, kidney problems and other serious events in people using unregulated products. There are no trials showing it is safe for cosmetic tanning.
How it is given
Subcutaneous injection or nasal spray (unapproved)
Commonly reported side effects
- Nausea
- Flushing
- New or darkening moles and freckles
- Spontaneous erections
- Reduced appetite
- Serious events reported in case reports
Questions to ask your provider
- Can you check my skin and moles?
- What are safer ways to get a tanned look?
- What should I do if a mole changes?