What it is
NAD+ is a coenzyme found in every cell. It helps turn food into energy and supports enzymes that repair DNA. It is not a peptide.
NAD+ levels fall with age, which has led to interest in raising them with supplements (such as nicotinamide riboside or NMN) or with NAD+ given by IV or injection at clinics.
US regulatory status
NAD+ is not an FDA-approved drug for any condition. IV and injectable NAD+ offered by clinics have not been reviewed by the FDA for safety or effectiveness.
What the research shows
Animal studies suggest raising NAD+ may improve some markers of aging and metabolism. Human studies of supplements show they can raise NAD+ levels, but benefits for health or aging have been small or unclear, and there is little quality research on IV or injected NAD+.
How it is given
IV infusion, injection, or oral precursors (supplements)
Commonly reported side effects
- Flushing
- Nausea
- Chest tightness or cramping during IV infusion
- Headache
- Injection site discomfort
- Limited long-term data
Questions to ask your provider
- Is there any reason for me to try NAD+ or its precursors?
- Could it interact with my medicines or conditions?
- What would we measure to know if it helps?